Etymology:
Meaning and Origin:
Creatinine is a waste product that is produced as a byproduct of muscle metabolism. The kidneys filter creatinine from the blood and excrete it in the urine.
The term creatinine was first used in 1832 by the French chemist Michel Eugène Chevreul. Chevreul isolated creatinine from urine and identified it as a crystalline substance that was soluble in water and alcohol. He named it "creatine" because he believed it was derived from "kreas" (flesh).
In 1858, the German chemist Justus von Liebig determined that creatinine was a product of muscle metabolism. He proposed that creatinine was formed from the degradation of creatine, a substance found in muscle tissue.
Creatinine is a useful marker for kidney function. Increased levels of creatinine in the blood may indicate impaired kidney function, as the kidneys are less able to filter creatinine from the blood. Conversely, decreased levels of creatinine may indicate reduced muscle mass.
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